Table 2.
Patient enrollment and log (meth-index) distribution in different centers.
| Normal | CIN1 | CIN2 | CIN3/CIS | SCC/AC | ||||||
|---|---|---|---|---|---|---|---|---|---|---|
| n | Mean ± SD | n | Mean ± SD | n | Mean ± SD | n | Mean ± SD | n | Mean ± SD | |
| PAX11 | ||||||||||
| TSGH | 130 | –1.9 ± 1.0 | 14 | –1.1 ± 1.5 | 7 | –2.2 ± 0.3 | 14 | –0.5 ± 2.2 | 10 | 2.1 ± 2.5 |
| NCKUH | 57 | –2.0 ± 1.0 | 12 | –2.3 ± 0.2 | 8 | –1.4 ± 1.5 | 14 | –0.2 ± 2.3 | 9 | 1.3 ± 2.9 |
| CGMH (Linkou) | 50 | –1.9 ± 1.2 | 21 | –2.0 ± 1.2 | 5 | –1.2 ± 1.7 | 8 | 0.6 ± 2.2 | 6 | 2.5 ± 0.7 |
| HTCMC | 48 | –2.0 ± 0.8 | 5 | –1.9 ± 0.4 | 3 | –1.1 ± 0.8 | 9 | 0.8 ± 2.3 | 3 | 3.1 ± 1.0 |
| CGMH (Kaohsiung) | 35 | –1.6 ± 1.5 | 17 | –1.6 ± 1.3 | 4 | –0.6 ± 1.9 | 12 | –1.0 ± 2.0 | 15 | 3.2 ± 0.7 |
| NTUH | 33 | –1.8 ± 1.3 | 1 | 1.3 | 2 | –2.4 ± 0.2 | 16 | –0.5 ± 2.4 | 0 | – |
| MMH | 31 | –1.8 ± 1.7 | 11 | –2.2 ± 1.2 | 4 | –1.6 ± 1.7 | 10 | –0.3 ± 2.3 | 2 | 3.7 ± 0.2 |
| VGH (Taichung) | 17 | –1.7 ± 1.5 | 6 | –1.5 ± 1.3 | 1 | 2.8 | 4 | 0.9 ± 2.2 | 4 | 1.8 ± 2.1 |
| CMUH | 2 | –2.2 ± 0.1 | 0 | – | 3 | –2.3 ± 0.4 | 1 | 3.7 | 0 | – |
| VGH (Kaohsiung) | 3 | –2.1 ± 0.3 | 0 | – | 0 | – | 2 | 2.1 ± 0.6 | 0 | – |
| VGH (Taipei) | 2 | –1.8 ± 1.0 | 0 | – | 0 | – | 1 | 1.6 | 0 | – |
| Total | 408 | –1.9 ± 1.2 | 87 | –1.8 ± 1.3 | 37 | –1.4 ± 1.5 | 91 | –0.1 ± 2.3 | 49 | 2.5 ± 1.9 |
| P value2 | 0.9498 | 0.0269 | 0.0742 | 0.3686 | 0.3090 | |||||
| SOX13 | ||||||||||
| TSGH | 130 | –0.6 ± 1.5 | 15 | –1.4 ± 1.2 | 7 | –0.4 ± 1.7 | 14 | 0.4 ± 1.7 | 10 | 2.8 ± 1.0 |
| NCKUH | 57 | –1.2 ± 1.3 | 12 | –0.2 ± 1.2 | 8 | –0.6 ± 1.3 | 14 | 0.2 ± 1.8 | 9 | 2.5 ± 0.8 |
| CGMH (Linkou) | 50 | –1.0 ± 1.5 | 21 | –0.4 ± 1.5 | 5 | –0.9 ± 1.6 | 8 | 1.2 ± 1.2 | 7 | 2.4 ± 0.6 |
| HTCMC | 48 | –0.8 ± 1.3 | 5 | –0.4 ± 1.2 | 3 | –0.6 ± 1.3 | 9 | 1.0 ± 1.7 | 3 | 2.8 ± 1.0 |
| CGMH (Kaohsiung) | 35 | –0.1 ± 1.3 | 17 | –0.9 ± 1.5 | 4 | –1.1 ± 1.6 | 12 | 0.2 ± 1.2 | 15 | 2.6 ± 1.0 |
| NTUH | 33 | –0.9 ± 1.6 | 1 | –2.2 | 2 | –2.3 ± 0.2 | 16 | 0.9 ± 1.5 | 0 | – |
| MMH | 31 | –0.5 ± 1.3 | 11 | –0.7 ± 1.6 | 4 | 0.2 ± 1.6 | 10 | 0.3 ± 2.0 | 2 | 3.2 ± 0.5 |
| VGH (Taichung) | 17 | –0.7 ± 1.4 | 6 | –1.0 ± 1.7 | 1 | 2.6 | 4 | 0.3 ± 1.9 | 4 | 1.7 ± 1.9 |
| CMUH | 2 | –2.2 ± 0.3 | 0 | – | 3 | –2.3 ± 0.4 | 1 | 3.5 | 0 | – |
| VGH (Kaohsiung) | 3 | –1.6 ± 0.9 | 0 | – | 0 | – | 2 | 2.5 ± 0.3 | 0 | – |
| VGH (Taipei) | 2 | –1.8 ± 1.0 | 0 | – | 0 | – | 1 | 1.7 | 0 | – |
| Total | 408 | –0.8 ± 1.4 | 88 | –0.7 ± 1.4 | 37 | –0.7 ± 1.5 | 91 | 0.6 ± 1.6 | 50 | 2.5 ± 1.0 |
| P value1 | 0.0206 | 0.3333 | 0.1419 | 0.3780 | 0.5948 | |||||
1
Four cases without methylation data.
2
By ANOVA.
3
Two cases without methylation data.