Table 3.
Sensitivities, specificities, and accuracies of detecting CIN3+ lesions using different methods in the testing set.
| Detection modality or test used | Sensitivity% (95% CI) | Specificity% (95% CI) | AUC | P-value |
|---|---|---|---|---|
| PAP | 91 (82–97) | 90 (86–93) | 0.91 (0.85–0.95) | <0.0001 |
| HPV | 89 (79–95) | 68 (62–73) | 0.78 (0.75–0.82) | <0.0001 |
| PAX1m | 64 (52–75) | 91 (86–94) | 0.77 (0.72–0.82) | <0.0001 |
| SOX1m | 71 (59–81) | 77 (72–82) | 0.83 (0.78–0.88) | <0.0001 |
| PAP | ||||
| or HPV | 97 (90–100) | 66 (60–72) | 0.82 (0.78–0.85) | <0.0001 |
| or PAX1m | 93 (87–99) | 84 (80–89) | 0.89 (0.86–0.92) | <0.0001 |
| or SOX1m | 96 (88–99) | 71 (65–76) | 0.83 (0.79–0.87) | <0.0001 |
| or (PAX1m or SOX1m) | 96 (88–99) | 69 (64–74) | 0.82 (0.78–0.86) | <0.0001 |
| or (PAX1m and SOX1m) | 93 (84–98) | 86 (81–90) | 0.90 (0.87–0.94) | <0.0001 |
| HPV | ||||
| or PAX1m | 94 (89–99) | 65 (59–70) | 0.79 (0.76–0.83) | <0.0001 |
| or SOX1m | 94 (90–98) | 54 (50–58) | 0.74 (0.70–0.78) | <0.0001 |
| and PAX1m | 57 (47–63) | 96 (90–99) | 0.77 (0.71–0.82) | <0.0001 |
| and SOX1m | 63 (51–74) | 93 (88–96) | 0.78 (0.73–0.83) | <0.0001 |
CIN, cervical intraepithelial neoplasia; CI, confidence interval; PAP, Pap smearing results; AUC, area under the curve; HPV, human papilloma virus level; PAX1m, methylated PAX1 level; SOX1m, methylated SOX1 level.