FIG. 2.

Ad-ISF35 induces A20 tumor necrosis and early infiltration of neutrophils and macrophages. Immunochemistry analysis of tumors harvested 24 hr after IDI with Ad-ISF35, Ad5, vehicle, and Ad-ISF35 heat inactivated at 72°C for 1 hr. Staining with anti-CD31 (endothelial cells), anti-GR1 (macrophages and neutrophils), anti-CD11b (granulocytes, macrophages, and monocytes), anti-F4/80 (macrophages), and anti-CD3 (T cells) antibodies is shown. Color images available online at www.liebertpub.com/hum