Table 3.
Quantification of 17q25.3 gain in BRCA1 -mutated and non-mutated TNBC by FISH
| BRCA1 | aCGH | FISH: mean number of 17qter copies | Mann-Whitney test | FISH: % cells with ratio >3 | Mann-Whitney test | ||||
|---|---|---|---|---|---|---|---|---|---|
| Gain in 17q25.3 | Median (IQR) | Median (IQR) | |||||||
| Number | + | − | aCGH | aCGH | P -value | aCGH | aCGH | P -value | |
| Gain in 17q25.3 | No gain in 17q25.3 | Gain in 17q25.3 | No gain in 17q25.3 | ||||||
| All | 44 | 26 | 18 | 3.6 (2.9 to 4.2) | 2.1 (1.7 to 2.6) | 0.0001 | 20.6 (11.5 to 35.4) | 0 (0 to 3.8) | 0.0001 |
| Mutated | 23 | 20 | 3 | 3.5 (2.7 to 4.2) | 1.8 (1.8 to 2.7) | 0.0199 | 20.6 (9.9 to 34.2) | 0 (0 to 10.6) | 0.0253 |
| Non-mutated | 21 | 6 | 15 | 3.6 (2.9 to 4.6) | 2.1 (1.7 to 2.6) | 0.0009 | 24.0 (14.1 to 33.9) | 0 (0 to 3.5) | 0.0007 |
TNBC, triple-negative breast cancer; aCGH, array comparative genomic hybridization.