Table 1.
Sox2 interacts with the promoters of stem cell and/or cancer-associated genes in RR cells
| NCBI gene symbol | Description | Final peak score |
|---|---|---|
| PLXNA2 | Plexin A2 | 3.19 |
| FZD4 | Frizzled homolog 4 (Drosophila) | 3.16 |
| MUC15 | Mucin 15, cell surface associated | 3.04 |
| PLAU | Plasminogen activator, urokinase | 2.89 |
| ELF5* | E74-like factor 5 (ets domain transcription factor) | 2.88 |
| VCAM1 | Vascular cell adhesion molecule 1 | 2.68 |
| DACH2 | Dachshund homolog 2 (Drosophila) | 2.55 |
| GPR49* | Leucine-rich repeat-containing G protein-coupled receptor 5 | 2.55 |
| FYB | FYN binding protein | 2.43 |
| COL4A5 | Collagen, type IV, alpha 5 | 2.40 |
| MYH9 | Myosin, heavy chain 9, non-muscle | 2.39 |
| PROM1 (CD133)* | Prominin 1 | 2.20 |
| ESR2 | Estrogen receptor 2 (ER beta) | 2.19 |
| PLAG1 | Pleiomorphic adenoma gene 1 | 2.19 |
| BMI1* | BMI1 polycomb ring finger oncogene | 2.17 |
List of RR ChIP-chip putative Sox2 target genes. Top-ranked 15 stem cell and/or cancer-associated genes of interest with >2.0 peak score derived from the MCF7 reporter responsive cells and their final adjusted microarray peak scores are summarized. The asterisks denote established stem cell markers.