Table 2.
The mean ±SD (and median) of percent excretion of different sugar probes in baseline urine permeability test and aspirin challenge permeability test in healthy controls, steatosis and non-alcoholic steatohepatitis in 5 and 24 h urine collection
| Healthy control (n = 12)
|
Steatosis (n = 6)
|
NASH (n = 10)
|
||||
|---|---|---|---|---|---|---|
| Baseline | Aspirin challenge | Baseline | Aspirin challenge | Baseline | Aspirin challenge | |
| Lactulose (5-h urine) | 0.07 ± 0.05 (0.05) | 0.06 ± 0.028 (0.07) | 0.23 ± 0.15 (0.18) | 0.17 ± 0.08 (0.19) | 0.14 ± 0.12 (0.10) | 0.62 ± 0.82 (0.39) |
| Mannitol (5-h urine) | 10.7 ± 9.1 (9.8) | 6.8 ± 2.9 (6.6) | 15.0 ± 4.9 (14.0) | 12.7 ± 8.0 (12.1) | 18.5 ± 12.1 (19.0) | 20.0 ± 12.9 (14.8) |
| L/M ratio (5-h urine) | 0.007 ± 0.003 (0.006) | 0.01 ± 0.005* (0.009) | 0.015 ± 0.008 (0.013) | 0.015 ± 0.001 (0.015) | 0.020 ± 0.035 (0.008) | 0.033 ± 0.034* (0.03) |
| Sucralose (24-h urine) | 2.49 ± 1.34 (2.08) | 2.62 ± 1.68 (2.49) | 3.07 ± 0.87 (3.23) | 4.11 ± 1.60 (4.05) | 2.79 ± 1.55 (2.90) | 7.70 ± 4.48 *#θ (6.3) |
*
P < 0.05 vs. healthy control at baseline.
#
P < 0.05 vs. NASH at baseline.
θ
P < 0.05 vs. steatosis post-aspirin.
L/M, lactulose/mannitol; NASH, non-alcoholic steatohepatitis; SD, standard deviation.