Table 3.
IPA functional analysis of sex-specific smoking correlated genes differentially expressed in smokers’ peripheral blood cells.
| Female | Male | ||||||
|---|---|---|---|---|---|---|---|
| Disease | p-valuea | #Genes b | p-value | #Genes | |||
| a) | Neurological disease | 6.25E-8 - 5.81E-3 | 54(8) | 4.06E-3 - 2.41E-2 | 8(2) | ||
| Rett syndrome | 2.73E-8 | 9 | |||||
| Psychological disorder | 5.03E-5 | 26 | |||||
| Mood disorder | 8.94E-5 | 20 | |||||
| Bipolar affective disorder 7.19E-5 | 18 | ||||||
| Taupathy | 1.58E-3 | 14 | |||||
| Encepahlopathy | 1.79E-5 | 10 | |||||
| Neuropathy | 2.04E-3 | 17 | |||||
| Neurodegenerative disease | 2.34E-3 | 14 | |||||
| Alzheimer’s disease | 3.72E-3 | 13 | |||||
| Neurological disorder | 5.81E-3 | 52 | 2.41E-2 | 8 | |||
| b) | Infectious disease | 9.17E-7 | 8(0) | 2.76E-2 | 1(0) | ||
| c) | Inflammatory disease/disorder | 1.49E-5 - 1.66E-3 | 40(6) | NSc | |||
| Inflammatory bowel disease | 1.42E-4 | 20 | |||||
| Crohn’s disease | 1.42E-4 | 19 | |||||
| Arthritis | 4.89E-4 | 24 | |||||
| Digestive system disorder | 1.47E-3 | 20 | |||||
| Genetic disorder of heart | 6.69E-5 | 3 | |||||
| d) | Cardiovascular disease | 2.25E-5 - 9.47E-03 | 32(3) | 5.58E-3 - 6.45E-2 | 13(9) | ||
| Atherosclerosis | 2.25E-5 | 21 | 3.99E-2 | 7 | |||
| Thrombosis | 2.26E-4 | 5 | |||||
| Coronary artery disease | 5.96E-4 | 17 | 6.54E-2 | 6 | |||
| Cardiovascular disorder | 1.17E-3 | 30 | 1.96E-2 | 13 | |||
| Myocardial infraction | 6.65E-3 | 4 | |||||
| Cardiac infraction | 9.47E-3 | 4 | 3.30E-2 | 1 | |||
| i) | Immunological diseases | 1.22E-4 - 5.09E-3 | 29(4) | 2.21E-2 | 2(2) | ||
| Rheumatoid arthritis | 3.31E-3 | 21 | |||||
| Autoimmune disease | 5.09E-3 | 27 | |||||
| j) | Hematopoiesis | 2.65E-4 | 13(0) | 1.01E-2 | 3(1) | ||
| k) | Respiratory disease | 3.99E-3 | 11(2) | 3.32E-2 | 2(1) | ||
| l) | Cancer | 5.28E-3 - 1.47E-2 | 19(5) | 3.07E-5 - 3.84E-2 | 14(6) | ||
| Hyperplasia of prostrate | NS | 3.07E-5 | 5 | ||||
| Hyperproliferation | NS | 3.29E-2 | 5 | ||||
| Colorectal cancer | 8.32E-3 | 13 | NS | ||||
| Epithelial ovarian cancer 9.18E-3 | 4 | NS | |||||
| Transformation | 1.22E-2 | 6 | NS | ||||
| m) | Diabetes mellitus | 8.31E-3 | 24(2) | 3.01E-3 | 11(6) | ||
| n) | Renal and urological disorder | 9.47E-3 | 10(0) | 5.58E-3 | 1(1) | ||
| o) | Organismal injury and abnormalities | 9.47E-3 | 9(0) | 5.58E-3 | 3(1) | ||
| p) | Connective tissue & muscular disorder | 9.47E-3 | 25(1) | NS | |||
a
The p-value is calculated using the right-tailed Fisher Exact Test.
b
The number of smoking-correlated genes in each category of functional assignments is presented. The number of genes up-regulated in each category is shown in parentheses.
c
NS: Not Significant.