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. 2014 Dec 12;54(2):557–566. doi: 10.1021/bi5013707

Figure 4.

Figure 4

Effect of helix discontinuities on the searching efficiency of truncated AAG. The processivity of Δ80 AAG was determined for a subset of oligonucleotide substrates containing a kink, bubble, and single-strand gap using a multiple-turnover processivity assay and compared to the results with a continuous duplex (reference). Data were collected at (A) 115 and (B) 150 mM NaCl with 2 nM Δ80 AAG and the indicated dsDNA substrate (200 nM). Values reflect the mean ± the standard deviation (n ≥ 4).