Figure 9.

Model for facilitated diffusion by AAG. Diffusion appears to be dominated by microscopic dissociation events in which the protein becomes at least partially solvated but is in the proximity of the DNA and is likely to reassociate. This state would resemble a transition state for dissociation.^13,22 At a high salt concentration, this species has a high probability of macroscopic dissociation that would be followed by three-dimensional diffusion. At lower salt concentrations, the vertical pathways dominate with hopping to either the same strand (top) or the opposing strand (bottom). Diffusion on duplex DNA is shown, but AAG can also diffuse along ssDNA.³¹