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Reactivation of GES-1, -2, and -5 after incubation with meropenem. The GES enzymes were incubated with meropenem (10–20 min for GES-1, 2–5 min for GES-2 and 30 s for GES-5) at 10-fold above Km, then diluted 1:1000 (panel A, GES-1), 1:200 (panel B, GES-2), or 1:50 (panel C, GES-5) in either nitrocefin (GES-1 and -2) or cephalothin (GES-5) (shown in gray). The line of best fit is shown in black. Control reactions (black) were run in the absence of meropenem.
