Table 2. Markers of renal dysfunction in HIV-infected children and HIV-uninfected siblings.
| HIV-infected cases | HIV-uninfected siblings | p-value | |
|---|---|---|---|
| (n = 122) | (n = 122) | ||
| n (%) or median [IQR] | n (%) or median [IQR] | ||
| Renal dysfunction* | 61 (50.0) | 51 (41.8) | 0.20 |
| eGFR † (ml/min/1.73 m2) | 112.9 [84.9–143–6] | 113.3 [91.4–134.2] | 1.0 |
| eGFR Category | |||
| Stage 1 (≥ 90) | 88 (72.1) | 95 (77.9) | 0.43 |
| Stage 2 (60–89) | 25 (20.5) | 21 (17.2) | |
| Stage 3 (30–59) | 9 (7.4) | 5 (4.1) | |
| Stage 4 (15–29) | 0 (-) | 0 (-) | |
| Stage 5 (< 15) | 0 (-) | 1 (0.8) | |
| Albuminuria | |||
| Negative | 68 (55.7) | 74 (60.7) | 0.88 |
| >20 mg/L | 38 (31.2) | 35 (28.7) | |
| >50 mg/L | 11 (9.0) | 9 (7.4) | |
| >100 mg/L | 5 (4.1) | 4 (3.3) | |
| Hematuria | 12 (9.8) | 13 (10.6) | 0.83 |
| Pyuria | 8 (6.6) | 6 (4.9) | 0.58 |
*the primary study outcome (defined operationally as eGFR <60mL/min/1.73m2 and/or albuminuria >20mg/L in a single urine test)
†eGFR = estimated glomerular filtration rate by modified Schwartz equation