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. Author manuscript; available in PMC: 2015 Jan 22.
Published in final edited form as: Pain. 2014 Mar 15;155(6):1161–1167. doi: 10.1016/j.pain.2014.03.004

Figure 2.

Figure 2

Water avoidance stress produces a persistent muscle hyperalgesia dependent on CCR2 expressed by IB4+ nociceptors. (A) Effect of intrathecal pre-treatment with IB4-saporin (n=6) or control treatment (saline 20 μl, n=6) on water avoidance stress-induced muscle hyperalgesia. (B) Effect of intrathecal IB4-saporin (open circle, n=6) or control treatment (i.t. saline 20 μl, n=6, solid circle) on water avoidance stress-induced hyperalgesic priming. PGE2 (1 μg/20 μl) was injected into the gastrocnemius muscle of rats previously exposed to water avoidance stress. (C) Effect of CCR2 AS/MM (n=6/group) in water avoidance stress-induced muscle pain. (D) Effect of CCR2 AS/MM (n=6/group) in rrMCP-1 (100 ng/20 μl) induced muscle hyperalgesia in naïve rats.