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. 2015 Jan 5;4(2):146–155. doi: 10.5966/sctm.2014-0181

Figure 1.

Figure 1.

Preparation of immunodeficient diabetic mice. (A): We prepared immunodeficient mice with diabetes mellitus (DM) for a wound healing experiment. To induce type 1 DM, STZ was injected intraperitoneally into 5-week-old male SCID mice that had been fasted for 24 hours. Three days after STZ (150 mg/kg) administration, hyperglycemia (blood glucose >300 mg/dl) was examined. When hyperglycemia was not observed, another STZ (150 mg/kg) injection was given. Skin defects were created on the back of DM-induced SCID mice at 9 weeks of age. (B): Typical changes in blood glucose level are shown. Hyperglycemia was achieved after one or two STZ injections at approximately 75%. Abbreviations: SCID, severe combined immunodeficiency; STZ, streptozotocin.