Table 1.

CNS monoamines are reduced in BN rats

Strain	n	Region	NA	P	DA	P	5-HT	P	5-HIAA	P
SS	6	Forebrain	348.7 ± 44.4		1250 ± 470.5		300.2 ± 32.6		328.8 ± 36
	6	Hypothalamus	1617.3 ± 95.4		207 ± 11.9		391.8 ± 21.6		622.4 ± 35
	5	Midbrain/pons	752.5 ± 37.2		187.9 ± 11.4		502.7 ± 15.7		611.6 ± 10.1
	6	Cerebellum	211.3 ± 11		ND		39.9 ± 2.6		ND
	5	Medulla	726 ± 43.4		56.5 ±		512.6 ± 14.2		486.4 ± 21.8
BN	4–6	Forebrain	236.9 ± 29.9		1427.2 ± 281		243.2 ± 20		196.7 ± 12.5*	0.006
	6	Hypothalamus	1073.3 ± 76.4*	0.001	235 ± 19.3		288.5 ± 10.4 *	0.002	411.7 ± 21.1 *	<0.001
	6	Midbrain/pons	601.5 ± 41.7 *	0.027	198.6 ± 12.2		534.8 ± 50.5		456.9 ± 45.4 *	0.014
	6	Cerebellum	189.6 ± 20.2		ND		25.7 ± 1.3 *	<0.001	ND
	6	Medulla	564.2 ± 47.5 *	0.036	39.9 ± *	0.021	400.6 ± 24.5 *	0.005	333.8 ± 23.8 *	0.001

Abbreviations: 5-HIAA, 5-hydroxyindolacetic acid; 5-HT, serotonin; BN, Brown Norway (rat); DA, dopamine; NA, noradrenaline; ND, not detectable; SS, Dahl salt-sensitive (rat). High-performance liquid chromatography measurements of NA, DA, 5-HT and its metabolite, 5-HIAA, were reduced in reduced in BN (n = 4–6) rats compared to SS (n = 6) rats (two-way ANOVA (strain and CNS region as factors) with Bonferroni post hoc;

^*P < 0.05).