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. 2015 Jan 22;10(1):e0117566. doi: 10.1371/journal.pone.0117566

Figure 4. Long-term maintenance of antigen-specific MBCs is impaired in CDH17-/- mice.

Figure 4

(A) Antigen-specific IgG1+ MBCs (Lin-B220+IgD-IgM-CD38+IgG1+NIP+) obtained from CDH17-/- mice and their WT littermates at 52 weeks after primary immunization with NP-CGG in alum were analyzed by flow cytometry. Numbers represent the percentage (%) of the indicated cell populations in the respective parental gates (shown on top of the panels). (B) The percentages of antigen-specific IgG1+ MBCs in their respective B220+ parental gate are plotted on a bar graph. The number of weeks post-immunization are shown for each bin. Each symbol represents an individual mouse (n = 6 (Week 0); n = 18 (Weeks 2–6); n = 19 (Weeks 50–67); **P≤0.01 (Mann-Whitney U-test)).