Table 2.
Univariate and multivariate Cox regression analysis of overall survival in NPC patients
| Parameters | Univariate analysis
|
Multivariate analysis
|
||||
|---|---|---|---|---|---|---|
| HR | 95% CI | P-value | HR | 95% CI | P-value | |
| Sex | ||||||
| Male vs female | 1.161 | 0.532–2.536 | 0.707 | – | – | – |
| Age (years) | ||||||
| <50 vs ≥50 | 0.989 | 0.961–1.017 | 0.427 | – | – | – |
| Histologic type | ||||||
| NKC vs KSCC | 1.642 | 0.482–2.439 | 0.641 | – | – | – |
| T stage | ||||||
| T1–2 vs T3–4 | 2.708 | 1.267–5.786 | 0.010 | – | – | – |
| N stage | ||||||
| N0–1 vs N2–3 | 9.260 | 3.228–26.563 | <0.001 | 7.892 | 2.731–22.807 | <0.001 |
| TNM stage | ||||||
| I–II vs III–IV | 9.086 | 2.164–38.153 | 0.003 | – | – | – |
| HMGA2 | ||||||
| Low vs high | 3.596 | 1.598–8.092 | 0.002 | 2.683 | 1.185–6.077 | 0.018 |
| Vimentin | ||||||
| Low vs high | 3.364 | 1.287–8.793 | 0.013 | – | – | – |
| E-cadherin | ||||||
| Low vs high | 0.344 | 0.147–0.802 | 0.014 | – | – | – |
Abbreviations: CI, confidence interval; HMGA2, high-mobility group protein 2; HR, hazard ratio; NPC, nasopharyngeal carcinoma; NKC, non-keratinizing carcinoma; KSCC, keratinizing squamous cell carcinoma.