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. 2015 Jan 17;10:665–675. doi: 10.2147/IJN.S76307

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© 2015 Situ et al. This work is published by Dove Medical Press Limited, and licensed under Creative Commons Attribution – Non Commercial (unported, v3.0) License

The full terms of the License are available at http://creativecommons.org/licenses/by-nc/3.0/. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.

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Cellular uptake results of DOX-loaded micelles.

Notes: Fluorescence images (A) of DOX after BEL-7402 and HepG2 cells were incubated with A54-Dex-PLGA/DOX micelles for 0.5, 4, and 10 hours. Quantitative analysis results (B) based on images (A) by ImageJ software. Fluorescence images (C) after BEL-7402 cells were incubated with DOX-loaded micelles solution for 2 and 24 hours. Quantitative cellular uptake (D) analyzed based on images (C) by a flow cytometry. Fluorescence images (E) of DOX after BEL-7402 was incubated with Dex-PLGA/DOX micelles, A54-Dex-PLGA/DOX micelles, and their blocking ones for 4 hours. Quantitative cellular uptake (F) analyzed based on images (E) by a flow cytometry (*P<0.05).

Abbreviation: A54-Dex-PLGA/DOX, doxorubicin-loaded A54 peptide-functionalized poly(lactic-co-glycolic acid)-grafted dextran.