Table II.

Summary of reported pharmacokinetic studies assessing steady state N-acetylcysteine concentrations in humans.

Reference	Patient group	Route of administration	Steady state plasma concentration (μM)
Ahola et al (1999)	Pre-term newborns	IV	510
Borgstrom et al (1986)	Pediatric	IV	400
	Adult	IV	200
Brown et al (2004)	Adult	IV	930
Jones et al (1997)	Adult	IV	210
Olsson et al (1988)	Adult	IV	37
Prescott et al (1989)	Adult	IV	230
De Caro et al (1989)	Adult	PO (single 600 mg dose)	33
Holdiness (1991)	Adult	PO	65

IV Intravenous; PO Oral. Adapted from Chen, et al (2007), with permission.