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Bath application of 4‐aminopyridine (4‐AP, 100 μM) induced membrane oscillations and an increase in spontaneous synaptic activity. At this holding potential (+10 mV), epileptiform activity is mainly mediated by GABAA receptors but also contributed by activation of glutamate receptors. Addition of the gap junctional blocker mefloquine (MFQ, 25 μM) decreased the amplitude and frequency of 4‐AP oscillations in two different cells from an RE case.
