Table 1.

Comparison of the cancer yield (cancers detected/1000 women screened) for mammography and various adjunct screening techniques (ultrasound, MRI, tomosynthesis and molecular breast imaging).

Supplemental screening modality	Cancers detected (n) per 1000 women screened	Cancers detected (n) per 1000 women screened + adjunct	Supplemental yield†	Increase in cancers detected (%)	Ref.
Ultrasound ACRIN 6666 year 1 dense breast + additional risk	7.5	12.8	5.3	71	[57]
Ultrasound ACRIN 6666 year 2, 3 dense breast + additional risk	8.1	11.8	3.7	46	[62]
MRI ACRIN 6666 year 3 dense breast + additional risk	8.2	26.1	17.9	220	[62]
Tomosynthesis (Skaane) age 50–69 years all densities	6.1	8.0	1.9	31	[9]
Tomosynthesis (Ciatto) age ≥48 dense subset	4.1	6.6	2.5	61	[58]
Automated ultrasound (Brem) dense breasts	5.4	7.3	1.9	35	[59]
Standard dose MBI dense breasts	3.2	10.7	7.4	231	[55]
Low-dose MBI dense breast	3.2	12.0	8.8	275	[56]

^†Supplemental yield is given as (number of cancers detected per 1000 women screened + adjunct) − (number of cancers detected per 1000 women screened). MBI: Molecular breast imaging.