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. Author manuscript; available in PMC: 2015 Jan 23.
Published in final edited form as: Neurobiol Dis. 2014 Sep 16;73:83–95. doi: 10.1016/j.nbd.2014.08.032

Fig. 1.

Fig. 1

Total and phosphorylated tau in the ipsilateral hemisphere of mice injected with tau PFFs. Sarkosyl soluble and insoluble brain fractions of the whole injected (right) hemisphere were analyzed for total and phosphorylated tau by Elisa. Injection of K18-PL (25 μg) in the hippocampus (A) or frontal cortex (B) induces a clear increase in both total and phosphorylated insoluble tau compared to buffer injected mice. This increase is observed for all three time points (1 m–2 m–3 m after K18-PL injection). A small increase in phosphorylation is also observed in the soluble brain fraction of K18-PL injected mice. One-way Anova *p < 0.05 vs buffer (n = 63 m buffer, n = 101 m–2 m K18-PL, n = 73 m K18-PL).