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. 2014 Nov 25;290(4):1927–1935. doi: 10.1074/jbc.M114.608703

FIGURE 5.

FIGURE 5.

Deficiency in SUMOylation enhances β-arrestin 2 inhibition of IL-1β-induced TNFα expression. A, quantitative real-time RT-PCR analysis showing the relative TNFα mRNA level in β-arrestin 2 WT- or β-arrestin 2 K295R-MCF-7 stable cell lines treated with IL-1β for the indicated time. The results are representative of three experiments. B, ELISA analysis showing the TNFα concentration in supernatants of β-arrestin 2 WT- or β-arrestin 2 K295R-MCF-7 stable cell lines after IL-1β stimulation. The results are representative of three experiments. **, p < 0.01.