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. 2014 Dec 10;290(4):1936–1951. doi: 10.1074/jbc.M114.598698

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FIGURE 9. — Comparison of 1NA-PP1 interactions in the nucleotide-binding pocket of AS and WT PKCδ. A and B, superimposed structure of 1NA-PP1 (colored by atom type) and ATP (yellow) in AS (A) and WT PKCδ (B). Ala-427 is highlighted in purple in AS PKCδ, and Met-427 is highlighted in green in WT PKCδ. C and D, 1NA-PP1-interacting residues in the nucleotide-binding pocket of AS (C) and WT PKCδ (D). 1NA-PP1 forms hydrogen bonds with Glu-428 and Leu-430 (red number symbols), and π-σ interaction with Lys-378 (red arrowheads). The gatekeeper is indicated by a red arrow.