TABLE 1.
In vivo kinetics of formate in folate-replete and folate-deficient rats
TTR ([13C]formate:[12C]formate), plasma formate concentration, and rate of endogenous formate production (per 100 g rat body weight) in folate-replete and folate-deficient rats after a constant infusion of sodium [13C]formate to isotopic steady state. Values are given as the mean ± S.D. for each group of rats. (n = 6).
| Kinetic Parameters | Folate-replete | Folate-deficient |
|---|---|---|
| Plateau TTR | 0.057 ± 0.017 | 0.099 ± 0.012a |
| Plasma formate concentration (μm) | 71 ± 28 | 271 ± 119a |
| Rate of endogenous formate production (μmol/h/100g) | 76.2 ± 15.8 | 43.5 ± 4.0a |
a A significant difference (p < 0.05) from the folate-replete value.