FIGURE 15.

DosR regulon during reaeration. The heat map shows the results of supervised hierarchical clustering focusing on the genes with the highest magnitude of change. The DosR regulon is induced in Mtb, whereas the response in Mtb:ΔRv2745c is ablated, indicating that Rv2745c plays a role in this regulatory network. n = 3. Red indicates induction, whereas blue indicates repression relative to the control channel. The intensity of each color corresponds to the magnitude. *, p < 0.05 for at least 1 time point.