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. 2014 Nov 24;290(4):2351–2367. doi: 10.1074/jbc.M114.615534

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FIGURE 7. — DosR regulon and EHR during hypoxia. Heat maps show the results of supervised hierarchical clustering. a, genes maximally induced in the DosR regulon. b, genes minimally induced in the DosR regulon. c, genes maximally induced in the EHR. d, genes minimally induced in the EHR. Genes induced in both the DosR regulon and the EHR in Mtb are induced as early as day 1 hypoxia, whereas there is a delayed response in Mtb:ΔRv2745c of genes that induced minimally in these pathways indicating that Rv2745c plays a role in these regulatory networks via direct or indirect regulation. n = 3. Red indicates induction, whereas blue indicates repression relative to the control channel. The intensity of each color corresponds to the magnitude. *, p < 0.05 for at least 1 time point.