FIGURE 8.
σH regulon during hypoxia. The heat map shows results of supervised hierarchical clustering focusing on the genes with the highest magnitude of change. Genes within the σH regulon are induced in Mtb during the initial stages of hypoxia, whereas only a subset of this regulon is induced in Mtb:ΔRv2745c, indicating that Rv2745c plays a differential regulatory role in a condition-dependent manner via direct or indirect regulation. n = 3. Red indicates induction, whereas blue indicates repression relative to the control channel. The intensity of each color corresponds to the magnitude. *, p < 0.05 for at least 1 time point.