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Structure of the LGR49-Rspo1 complex. A, domain structures of LGR49 and Rspo1. LGR49 and the two central furin-like domains (Fu1 and Fu2, colored in purple) of Rspo1 were co-expressed for the LGR4-Rspo1 complex. B, structure of the LGR49-Rspo1 complex. Rspo1 is colored in purple. The central nine LRR repeats of LGR49 are colored in green. The LRRNT and VLR subdomains of LGR49 are colored in orange and cyan, respectively.
