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. Author manuscript; available in PMC: 2015 Jan 23.
Published in final edited form as: J Lipid Res. 2007 Mar 20;48(6):1253–1262. doi: 10.1194/jlr.R700005-JLR200

Fig. 2.

Fig. 2

The transcriptional control of adipogenesis involves the sequential activation of a transcription factor cascade. This begins with the transient expression of C/EBPβ and C/EBPδ, followed by C/EBPα, which in turn activates peroxisome proliferator-activated receptor γ 2 (PPARγ2). The latter pair is primarily responsible for switching on the broad program of adipogenesis. In addition, PPARγ exerts positive feedback on C/EBPα and acts synergistically to maintain the differentiated state. Sterol-regulatory element binding protein 1c (SREBP1c) is regulated by insulin and lipids and can activate PPARγ by inducing its expression as well as by promoting the production of an endogenous PPAR ligand. SREBP1c also activates the expression of many genes of the lipogenic program. Together, these factors contribute to the expression of genes that characterize the terminally differentiated phenotype. GATA, GATA binding protein; IBMX, 3-Isobutyl-1-methylxanthine; PEPCK, phosphoenolpyruvate carboxykinase; TZD, thiazolidinedione.