Figure 6.

Sleep architecture is unaffected by drug infusion. Post-MD sleep characteristics are displayed as 6-hour averages for simplicity, but were divided into 2-hour bins for statistical analysis (see Results; no significant effects of drug or drug × time interaction were observed). Sleep architecture was determined using frontoparietal EEG and EMG recordings. Vehicle N = 4 cats; U0126 N = 4; CGP57380 N = 3. (A) Mean (±SD) amounts of wake, REM sleep, and NREM sleep during baseline, MD, and post-MD recording periods. (B) Mean (±SD) duration of wake, REM sleep, and NREM sleep bouts during the post-MD infusion period. (C) Average (±SD) number of transitions from sleep to wake and total number of transitions between all arousal states during the post-MD period.