Table 1.
Overview of KCh Subcellular Localization in Mammalian Brain
| Subunit | Gene | AKA | Predominant localization in brain |
|---|---|---|---|
| KCa1.1 | KCNMA1 | BK, Slo1 | Axons, terminals |
| KCa2.1 | KCNN1 | SK1 | Dendrites |
| KCa2.2 | KCNN2 | SK2 | Dendrites/spines |
| KCa2.3 | KCNN3 | SK3 | Axons, terminals |
| KCa3.1 | KCNN4 | IKCA1, SK4 | Somata, dendrites |
| KCa4.1 | KCNT1 | Slack, Slo2.2 | Somatodendritic |
| KCa4.2 | KCNT2 | Slick, Slo2.1 | Somatodendritic |
| Kir2.2 | KCNJ12 | IRK2 | Dendritic |
| Kir2.3 | KCNJ4 | IRK3 | Axons/terminals |
| Kir3.1 | KCNJ3 | GIRK1 | Dendrites/spines |
| Kir3.2 | KCNJ6 | GIRK2 | Dendrites/spines |
| Kir3.3 | KCNJ9 | GIRK3 | Axons/terminals |
| Kir6.2 | KCNJ11 | KATP | Dendrites |
| Kv1.1 | KCNA1 | AIS, axon preterminals, JPN | |
| Kv1.2 | KCNA2 | AIS, axon preterminals, JPN | |
| Kv1.3 | KCNA3 | CoH terminals, microglia | |
| Kv1.4 | KCNA4 | Axon preterminals | |
| Kv1.6 | KCNA6 | Somatodendritic | |
| Kv2.1 | KCNB1 | Somata, proximal dendrites, AIS | |
| Kv2.2 | KCNB2 | Somata, proximal dendrites, AIS | |
| Kv3.1 | KCNC1 | Terminals, NoR | |
| Kv3.2 | KCNC2 | Terminals | |
| Kv3.3 | KCNC3 | Terminals | |
| Kv3.4 | KCNC4 | Terminals | |
| Kv4.2 | KCND2 | Dendrites/spines | |
| Kv4.3 | KCND3 | Dendrites/spines | |
| Kv7.2 | KCNQ2 | KCNQ2 | AIS, NoR, axons |
| Kv7.3 | KCNQ3 | KCNQ3 | AIS, NoR, axons |
| Kv7.5 | KCNQ5 | KCNQ5 | Terminals CoH |
| Non-neuronal cells | K2p3.1, Kir4.1, Kir6.1, Kv1.5 | ||
| Intracellular | K2p1.1, K2p2.1, K2p4.1, K2p5.1, K2p6.1, K2p9.1, K2p10.1, K2p18.1, Kir2.4, Kir3.4, Kv4.1, Kv10.1, Kv10.1, Kv11.1, Kv11.2 | ||
| No reports | K2p7.1, K2p12.1, K2p13.1, K2p15.1, K2p16.1, K2p17.1, KCa5.1, Kir1.1, Kir4.2, Kir5.1, Kir7.1, Kv1.7, Kv1.8, Kv5.1, Kv6.1, Kv6.2, Kv6.3, Kv6.4, Kv7.1, Kv7.4, Kv8.1, Kv8.2, Kv9.1, Kv9.2, Kv9.3, Kv12.1, Kv12.2, Kv12.3 | ||