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. 2015 Jan 13;7(1):97–109. doi: 10.3390/toxins7010097

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© 2015 by the authors; licensee MDPI, Basel, Switzerland.

This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/4.0/).

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Kidney phenotypes of zebrafish embryos after prevention (10 ppm Resv or UA). (A) No defect of mock group; (B) AA caused atrophic glomerulus and pronephric tube (pt) curved defect; (C and D) Prevention groups treated to restore a similar phenotype as the mock group. All kidney photos were taken from the dorsal view at the developmental stage of 48 hpf. Tg(wt1b:EGFP). pt, pronephric tubule; pd, pronephric duct; gl, glomerulus; (E,F) The Tukey-Kramer HSD (honestly significant difference) test: the mean malformation rates and their 95% confidence intervals for treatment groups. Two group means were considered significantly different if their intervals were disjointed and were not significantly different if their intervals overlapped.

Kidney phenotypes of zebrafish embryos after prevention (10 ppm Resv or UA). (A) No defect of mock group; (B) AA caused atrophic glomerulus and pronephric tube (pt) curved defect; (C and D) Prevention groups treated to restore a similar phenotype as the mock group. All kidney photos were taken from the dorsal view at the developmental stage of 48 hpf. Tg(wt1b:EGFP). pt, pronephric tubule; pd, pronephric duct; gl, glomerulus; (E,F) The Tukey-Kramer HSD (honestly significant difference) test: the mean malformation rates and their 95% confidence intervals for treatment groups. Two group means were considered significantly different if their intervals were disjointed and were not significantly different if their intervals overlapped.