. 2015 Jan 23;5:7986. doi: 10.1038/srep07986

Table 2. Meta-analysis of the association between PLCE1 rs2274223 A > G polymorphism and cancer risk.

Variables	G vs. A			GG vs. AA			GA vs. AA			GG/GA vs. AA			GG vs. GA/AA
Variables	OR (95% CI)	P_OR^a	P_het^b	OR (95% CI)	P_OR^a	P_het^b	OR (95% CI)	P_OR^a	P_het^b	OR (95% CI)	P_OR^a	P_het^b	OR (95% CI)	P_OR^a	P_het^b
All	1.15 (1.06–1.25)	0.001	0.000	1.30 (1.10–1.55)	0.003	0.000	1.18 (1.08–1.30)	0.001	0.000	1.20 (1.08–1.32)	0.000	0.000	1.22 (1.04–1.42)	0.012	0.001
Cancer Type
GC	1.11 (0.95–1.31)	0.184	0.000	1.26 (0.94–1.68)	0.118	0.010	1.12 (0.92–1.37)	0.253	0.000	1.14 (0.93–1.39)	0.217	0.000	1.22 (0.96–1.54)	0.100	0.057
ESCC	1.25 (1.08–1.44)	0.002	0.000	1.55 (1.17–2.06)	0.002	0.015	1.27 (1.09–1.47)	0.002	0.034	1.30 (1.10–1.53)	0.002	0.004	1.39 (1.10–1.77)	0.007	0.059
EAC	1.07 (0.88–1.29)	0.503	0.883	1.17 (0.75–1.81)	0.495	0.474	1.05 (0.81–1.37)	0.707	0.511	1.07 (0.83–1.37)	0.601	0.720	1.14 (0.75–1.74)	0.534	0.333
Colorectal	1.02 (0.53–1.95)	0.948	0.001	0.74 (0.13–4.33)	0.742	0.003	1.17 (0.71–1.92)	0.532	0.038	1.10 (0.58–2.10)	0.760	0.005	0.71 (0.15–3.44)	0.668	0.006
HNC	1.14 (0.95–1.38)	0.167	/	1.70 (1.02–2.86)	0.044	/	1.03 (0.81–1.30)	0.807	/	1.09 (0.87–1.37)	0.430	/	1.69 (1.01–2.81)	0.045	/
SCCHN	1.07 (0.94–1.21)	0.291	/	1.09 (0.81–1.45)	0.580	/	1.13 (0.94–1.35)	0.183	/	1.12 (0.95–1.33)	0.188	/	1.02 (0.78–1.35)	0.878	/
GBC	1.09 (0.85–1.40)	0.512	/	0.52 (0.24–1.12)	0.094	/	1.49 (1.07–2.09)	0.020	/	1.35 (0.98–1.88)	0.068	/	0.42 (0.20–0.89)	0.024	/
Publication Bias^c		0.846			0.586			0.831			0.983			0.580

^aP value of the Z-test for odds ration test;

^bP value of the Q-test for heterogeneity test;

^cP value of Egger's test for publication bias; GC, gastric cancer; ESCC, esophageal squamous cell carcinoma; EAC, esophageal adenocarcinoma; SCCHN, squamous cell carcinoma of head and neck; HNC, head and neck cancer; GBC, gallbladder cancer.