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. 2015 Jan 23;5:7986. doi: 10.1038/srep07986

Table 3. Meta-analysis of the association between PLCE1 rs2274223 A > G polymorphism and different types of cancer (GC and ESCC) risk.

Variables G vs. A GG vs. AA GA vs. AA GG/GA vs. AA GG vs. GA/AA
OR (95% CI) PORa Phetb OR (95% CI) PORa Phetb OR (95% CI) PORa Phetb OR (95% CI) PORa Phetb OR (95% CI) PORa Phetb
GC 1.11 (0.95–1.31) 0.184 0.000 1.26 (0.94–1.68) 0.118 0.010 1.12 (0.92–1.37) 0.253 0.000 1.14 (0.93–1.39) 0.217 0.000 1.22 (0.96–1.54) 0.100 0.057
Ethnicity                              
 Asian 1.15 (0.94–1.42) 0.180 0.000 1.34 (0.92–1.95) 0.127 0.004 1.15 (0.89–1.48) 0.278 0.000 1.17 (0,90–1.52) 0.228 0.000 1.29 (0.96–1.74) 0.096 0.031
 Caucasian 1.03 (0.87–1.22) 0.732 0.409 1.06 (0.72–1.55) 0.772 0.623 1.06 (0.81–1.38) 0.679 0.287 1.05 (0.82–1.35) 0.682 0.293 1.01 (0.70–1.44) 0.967 0.879
Source of control                              
 PB 1.15 (0,91–1.47) 0.237 0.011 1.37 (0.81–2.33) 0.241 0.019 1.19 (0.97–1.47) 0.097 0.157 1.20 (0.93–1.55) 0.161 0.056 1.29 (0.81–2.06) 0.288 0.030
 HB 1.07 (0.88–1.32) 0.487 0.005 1.13 (0.93–1.37) 0.233 0.511 1.09 (0.79–1.50) 0.601 0.000 1.09 (0,81–1.47) 0.561 0.001 1.13 (0.93–1.37) 0.211 0.723
Genotyping methods                              
 TaqMan 1.20 (1.04–1.39) 0.015 0.029 1.39 (0.97–2.00) 0.073 0.033 1.27 (1.12–1.44) 0.000 0.254 1.28 (1.10–1.49) 0.001 0.122 1.28 (0.92–1.78) 0.135 0.049
 MassArray 1.03 (0.77–1.37) 0.848 / 0.91 (0.45–1.83) 0.783 / 1.12 (0.77–1.61) 0.556 / 1.08 (0.76–1.52) 0.668 / 0.87 (0.44–1.74) 0.698 /
 HRM 0.96 (0.87–1.05) 0.342 / 1.07 (0.84–1.37) 0.561 / 0.88 (0.77–0.99) 0.034 / 0.90 (0.80–1.01) 0.086 / 1.14 (0.90–1.44) 0.293 /
Sample size                              
 >1000 1.18 (0.93–1.51) 0.173 0.000 1.44 (0.95–2.20) 0.090 0.002 1.16 (0.86–1.57) 0.333 0.000 1.20 (0.88–1.63) 0.250 0.000 1.37 (0.99–1.89) 0.059 0.025
 ≤1000 1.03 (0.89–1.19) 0.695 0.711 1.02 (0.73–1.43) 0.902 0.824 1.08 (0.88–1.32) 0.481 0.552 1.06 (0.87–1.29) 0.543 0.572 0.98 (0.71–1.34) 0.887 0.925
HWE                              
 Yes 1.14 (0.96–1.36) 0.136 0.000 1.30 (0.96–1.78) 0.095 0.007 1.16 (0.93–1,44) 0.190 0.000 1.17 (0.94–1.47) 0.158 0.000 1.24 (0.96–1.60) 0.096 0.040
 No 0.95 (0.73–1.23) 0.682 / 0.92 (0.47–1.81) 0.809 / 0.91 (0.63–1.32) 0.629 / 0.91 (0.64–1.31) 0.622 / 0.97 (0.51–1.85) 0.917 /
ESCC 1.25 (1.08–1.44) 0.002 0.000 1.55 (1.17–2.06) 0.002 0.015 1.27 (1.09–1.47) 0.002 0.034 1.30 (1.10–1.53) 0.002 0.004 1.39 (1.10–1.77) 0.007 0.059
Ethnicity                              
 Asian 1.44 (1,25–1.66) 0.000 0.059 2.04 (1.47–2.85) 0.000 0.119 1.39 (1.24–1.56) 0.000 0.471 1.49 (1.29–1.72) 0.000 0.182 1.76 (1.31–2.36) 0.000 0.195
 Caucasian 0.82 (0.59–1.13) 0.225 0.264 0.71 (0.35–1.46) 0.354 0.905 0.73 (0.35–1.51) 0.393 0.067 0.73 (0.39–1.37) 0.323 0.097 0.80 (0.40–1.61) 0.539 0.723
 African 1.06 (0.89–1.25) 0.521 / 1.10 (0.78–1.57) 0.587 / 1.09 (0.84–1.42) 0.510 / 1.09 (0.85–1.40) 0.474 / 1.05 (0.76–1.43) 0.776 /
 Mixed 1.16 (0.95–1.42) 0.139 / 1.32 (0.87–1.99) 0.196 / 1.27 (0.92–1.74) 0.145 / 1.28 (0.95–1.73) 0.109 / 1.14 (0.79–1.65) 0.478 /
Source of control                              
 PB 1.07 (0.57–2.02) 0.828 0.000 1.28 (0.39–4.14) 0.683 0.004 1.00 (0.50–2.03) 0,992 0.001 1.03 (0.48–2.21) 0.942 0.000 1.33 (0.52–3.38) 0.552 0.027
 HB 1.29 (1.19–1.41) 0.000 0.496 1.61 (1.29–2.03) 0.000 0.365 1.33 (1.18–1.49) 0.000 0.950 1.37 (1.23–1.53) 0.000 0.829 1.42 (1.13–1.77) 0.002 0.338
 Mixed 1.06 (0.89–1.25) 0.521 / 1.10 (0.7–1.57) 0.587 / 1.09 (0.84–1.42) 0.510 / 1.09 (0.85–1.40) 0.474 / 1.05 (0.76–1.43) 0.776 /
Genotyping methods                              
 TaqMan 1.08 (0.93–1.25) 0.300 0.077 1.22 (0.99–1.50) 0.065 0.464 1.09 (0.88–1.35) 0.417 0.065 1.09 (0.88–1.35) 0.420 0.045 1.13 (0.93–1.36) 0.224 0.712
 MassArray 1.40 (1.10–1.78) 0.006 / 1.82 (0.99–3.33) 0.052 / 1.42 (1.05–1.94) 0.024 / 1.48 (1.11–1.98) 0.008 / 1.59 (0.88–2.88) 0.124 /
 PCR-LDR 1.35 (1.11–1.64) 0.003 / 1.76 (1.06–2.92) 0.029 / 1.39 (1.08–1.80) 0.011 / 1.44 (1.13–1.84) 0.004 / 1.52 (0.93–2.50) 0.096 /
 PCR-RFLP 1.86 (1.48–2.35) 0.000 / 3.46 (1.87–6.38) 0.000 / 1.78 (1.31–2.40) 0.000 / 1.97 (1.48–2.62) 0.000 / 2.80 (1.53–5.11) 0.001 /
 MALDI-TOF MS 1.54 (1.16–2.05) 0.003 / 3.17 (1.45–6.93) 0.004 / 1.39 (0.95–2.02) 0.087 / 1.55 (1.08–2.22) 0.017 / 2.76 (1.28–5.93) 0.009 /
Sample size                              
 >1000 1.20 (1.09–1.32) 0.000 0.274 1.34 (1.10–1.64) 0.004 0.468 1.26 (1.12–1.41) 0.000 0.620 1.28 (1.14–1.43) 0.000 0.482 1.20 (1.00–1.45) 0.050 0.565
 ≤1000 1.25 (0.92–1.70) 0.146 0.000 1.74 (0.94–3.21) 0.078 0.014 1.21 (0.87–1.69) 0.264 0.006 1.25 (0.87–1.80) 0.220 0.001 1.67 (1.01–2.75) 0.046 0.068
Score                              
 High 1.22 (1.05–1.41) 0.011 0.000 1.46 (1.10–1.93) 0.008 0.034 1.25 (1.06–1.47) 0.008 0.021 1.27 (1.06–1.52) 0.009 0.003 1.32 (1.05–1.65) 0.017 0.125
 Low 1.54 (1.16–2.05) 0.003 / 3.17 (1.45–6.93) 0.004 / 1.39 (0.95–2.02) 0.087 / 1.55 (1.08–2.22) 0.017   2.76 (1.28–5.93) 0.009 /
HWE                              
 Yes 1.29 (1.13–1.47) 0.000 0.003 1.62 (1.21–2.15) 0.001 0.016 1.32 (1.19–1.46) 0.000 0.367 1.37 (1.20–1.56) 0.000 0.071 1.42 (1.10–1.83) 0.007 0.040
 No 0.66 (0.40–1.07) 0.095 / 0.67 (0.21–2.16) 0.508 / 0.48 (0.25–0.92) 0.028 / 0.51 (0.27–0.94) 0.031 / 0.95 (0.30–2.94) 0.924 /

aP value of the Z-test for odds ration test;

bP value of the Q-test for heterogeneity test; GC, gastric cancer; ESCC, esophageal squamous cell carcinoma; PB, Population based; HB, Hospital based; PCR-LDR, polymerase chain reaction ligase detection reaction; PCR-RFLP, Polymorphism chain reaction-restriction fragment length polymorphism; MALDI-TOF MS, matrix assisted laser desorption ionization/time of flight mass spectrometry; HRM, high-resolution melting; HWE, Hardy-Weinberg equilibrium.