Figure 5. Molecular docking analyses of T1 and T2 toward mushroom tyrosinase.

(a) The docking model of T1 molecule in the active site of mushroom tyrosinase. T1 molecule is colored in cyan, and residues interacting with T1 are colored in white and orange (6 histidine residues). (b) The docked T2 molecule (colored in green) interacts with the active site residues (colored in white and orange) of mushroom tyrosinase. (c) 2D schematic representation of the interactions between T1 and active site residues of mushroom tyrosinase. (d) 2D schematic representation of the interactions between T2 and active site residues of mushroom tyrosinase. (The green dash lines in a and b panels donate the hydrogen bond interactions, the yellow ones represent the hydrophobic interactions, and the red spheres represent two cooper ions. In 2D schemes, green dash line denotes hydrogen bond interaction; circles in distinct colors represent the relative hydrophobic and/or π-π interactions).