Figure 1. Cytotoxicity of cordycepin.

A cytotoxicity assay was performed using a cell counting assay (CCK-8 kit) to determine if cordycepin causes cytotoxicity. Cordycepin cytotoxic to SNU719 cells that latently infected by Epstein-Barr virus(EBV). The same methods were used to test the cytotoxicity of adenosine and its analogs. (A) Structures of cordycepin, adenosine, 2′-deoxyadenosine, and 2′,3′-dideoxyadenosine. (B) 50% cytotoxicity dose (CD₅₀) of cordycepin and its analogs in SNU719 cells. Each measurement was repeated three times. Averages and standard errors of measurements are displayed on the graphs.