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. 2014 Dec 18;1(12):866–881. doi: 10.18632/oncoscience.110

Figure 8. Effect of cordycepin on EBV latency promoter selection.

Figure 8

An RT-PCR assay was performed to determine if cordycepin affects the selection of EBV latency promoters. (A) As controls, KEM1 cells (specific to EBV type I) showed a high frequency of Qp and Fp promoter usage. KEM3 cells (specific to EBV type III) showed a high frequency of Cp/Wp promoter usage. (B) Cordycepin decreased frequencies of Qp and Fp promoter usage, but did not affect Cp/Wp promoter activity. (C) Combined treatment of cordycepin with HDAC inhibitors such as NaB and TPA did not reduce Qp and Fp promoter activities. Cp, Wp, Qp, and Fp are EBV promoters activated depending on the EBV latency type [17].