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. Author manuscript; available in PMC: 2015 Jan 23.
Published in final edited form as: Curr Immunol Rev. 2011;7(3):344–349. doi: 10.2174/157339511796196584

Fig. (1). Inhibition of the DTH (ear swelling) response to βgal in arrβal mice.

Fig. (1)

A. ACAID-induced and spontaneous downregulation of the DTH response to βgal. Indicated strain of mice were given a primary challenge either by immunization (βgal + CFA) or by infection (βgal vaccinia virus). Where indicated, some mice were given an injection of saline or βgal into the anterior chamber of the eyes to induce ACAID seven days prior to the primary challenge. All mice were given a second challenge of βgal into the ear pinna seven days after the primary challenge and DTH was assayed by ear swelling 48 hours later. All results given as mean ± SD, * = p < 0.05 (t test) compared to similarly treated B10.A mice. B. DTH inhibition is mediated by arrβgal CD3+4+25+ T cells. B10.A mice were transferred with the indicated fraction of arrβgal splenocytes and infected one day later with βgal vaccinia virus. DTH was assayed by ear swelling four weeks post-infection and measured at 48 hours. All results given as mean ± SD, * = p < 0.01 (t test) compared to mice transferred with whole splenocytes, NS = not significant (p > 0.05).