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. 2015 Feb;159:127–137. doi: 10.1016/j.aquatox.2014.12.007

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© 2014 The Authors

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Fig. 2 — The apparent permeability coefficients (P_app) for uptake (P_app_A:B, white bars) and efflux (P_app_B:A, gray bars) of seven pharmaceuticals (1 μg L⁻¹) across the DSI gill cell epithelium at 6 h in symmetrical conditions (A) and asymmetrical conditions (B). Significant differences between the P_app_A:B and P_app_B:A for a drug within a condition (symmetrical or asymmetrical) are indicated by asterisk (independent samples t-test; ***P < 0.001). Significant differences between symmetrical and asymmetrical P_app_A:B or P_app_B:A for each drug are indicated by hash tag in (B) (independent samples t-test; ^#P < 0.05). All experiments were performed in triplicate or more (n = 3–5) from at least one biological replicate and values are shown as means ± SEM.