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. 2014 Jul 30;61(1):88–97. doi: 10.1002/hep.27192

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© 2014 The Authors. Hepatology published by Wiley on behalf of the American Association for the Study of Liver Diseases.

This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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Fig. 1 — Comparison of viral complexity in paired serum samples (pre- and posttreatment) in patient -P63, Null response, Persistent infection. (A) A Maximum likelihood tree was constructed using nucleotide sequences from paired samples and selected HCV reference sequences for the Los Alamos HCV database. A total of 4 (A-D) HCV variants detected. The analysis included; 25 clonal sequences (posttreatment), and 46156 reads derived from 454 pyrosequencing (pretreatment). There were a total of 183 positions in the final dataset. (B) Bubble chart of the frequency of each variant (A-D) in pre- and posttreatment samples. (C) Pairwise distance between the most similar variants in the pre- and posttreatment samples (p-distance).