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. 2014 Dec 19;15(Suppl 12):S3. doi: 10.1186/1471-2164-15-S12-S3

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Copyright © 2014 Korbolina et al.; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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The distribution of SNPs specific to the parental strains, on chromosome 1 of the congenic rats: WAG/OXYS-1.1 (panel A) and WAG/OXYS-1.2 (panel C). Panel B shows a plot of distribution of retinopathy linkage probability (LOD score) among the F2 progeny derived from OXYS and WAG strains at age 3 months (using microsatellite markers on chromosome 1). The dotted vertical line at LOD = 2.0 is the threshold for suggestive statistical significance. Red bars correspond to individual SNPs, specific to WAG rats, blue - to OXYS rats. COUNT - a number of coding SNPs for 1 Mbp. The OXYS-derived loci of chromosome 1 transferred to the recipient WAG genome during the construction of the corresponding congenic strains are shown as green (expected) and blue (the congenic segment) inserts, to the left of the linkage map. The blue dotted lines are designed to compare the certain congenic loci between the panels. Note, that the transferred locus was not what we expected in WAG/OXYS-1.1 rats.