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. 2014 Dec 19;15(Suppl 12):S9. doi: 10.1186/1471-2164-15-S12-S9

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Copyright © 2014 Duk et al.; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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The incoherent and coherent feed-forward loops. Arrows mean activation, the turned over T-bars indicate repression. TF-transcription factor, miR-miRNA, Target - target protein. A: 1In - type 1 incoherent FFL, TF activates both target mRNA and miRNA synthesis. B: 1C - type 1 coherent FFL, TF represses traget mRNA and activates miRNA synthesis. C: 2In - type 2 incoherent FFL, TF represses both target mRNA and miRNA synthesis. D: 2C - type 2 coherent FFL, TF activates target mRNA and represses miRNA synthesis.