FIG. 2.

Physiological characterization of PPARγ2 knockout mouse. A: Body weights of males (○, wild type; □, heterozygous; •, PPARγ2 knockout; n = 20) fed a normal diet (left) or an HFD (right). B: Food intake from 20-week normal diet–fed mice (n = 7). C: Body composition analysis from 32-week-old male wild-type and PPARγ2 knockout mice fed a normal diet and a 28-week HFD (n = 5). D: Fat-selective MRI from 32-week-old male PPARγ2 knockout (a) and wild-type (b) mice (n = 5). Regions of interest (epididymal WAT [Epi], perirenal WAT [Perir], omental WAT [oMen], skin, subcutaneous WAT [SC]) were delineated in each fat-selective image, and their total signal intensity was calculated by summing the data from each slice. The results are expressed as a percentage of each fat region from total fat. KO, knockout; WT, wild type. *P < 0.05; §P < 0.01.