TABLE 3.
SNPs in the SLIT3 and DHRS2 regions associated with serum lycopene in African Americans1
| Nearest gene | Chr | SNP | A1/A2 | P | β | CAF | MAF |
| SLIT3 | 5 | rs78219687* | G/A | 9.87 × 10−9 | 0.39 | 0.95 | 0.05 |
| rs114819789 | G/A | 3.44 × 10−8 | 0.41 | 0.95 | 0.05 | ||
| rs74659379 | G/T | 3.42 × 10−8 | 0.41 | 0.95 | 0.05 | ||
| rs114731073 | A/T | 3.40 × 10−8 | 0.41 | 0.95 | 0.05 | ||
| DHRS2 | 14 | rs74036811* | C/G | 9.54 × 10−9 | 0.38 | 0.95 | 0.05 |
| rs17095390 | G/C | 9.55 × 10−8 | 0.38 | 0.95 | 0.05 | ||
| rs17095435 | C/T | 2.22 × 10−8 | 0.39 | 0.95 | 0.05 |
1
Baseline model was further adjusted for age, BMI, and first 4 principal components of ancestry. *SNP with the most significant association in African Americans with serum lycopene for this region. A1/A2, coded/non-coded allele; CAF, coded allele (A1) frequency; Chr, chromosome number; DHRS2, dehydrogenase/reductase (SCR family) member 2; MAF, minor allele frequency; SLIT3, slit homolog 3; SNP, single nucleotide polymorphism.