TABLE 1.
Body weight and serum concentrations of 25(OH)D3 and calcium in Pirc/+ rats fed diets supplemented with vitamin D3 or 25(OH)D31
| Females |
Males |
Serum 25(OH)D3 |
Serum calcium |
|||||||
| Dietary compound and dose2 | Rats, n | Weight,3 g | Rats, n | Weight,3 g | Samples, n | Concentration,4 μg/L | P-trend | Samples, n | Concentration,4 mg/dL | P-trend |
| 25(OH)D3 [μg/(kg body weight · d)] | <0.00001 | <0.00001 | ||||||||
| 0 | 17 | 221 ± 13 | 6 | 375 ± 24 | 10 | 33 ± 5 | 17 | 11.6 ± 0.1 | ||
| 60 | 6 | 218 ± 14 | 4 | 369 ± 4 | 4 | 115 ± 11 | 10 | 12.2 ± 0.1 | ||
| 170 | 5 | 218 ± 8 | 5 | 323 ± 26 | 4 | 106 ± 12 | 10 | 12.7 ± 0.1 | ||
| 500 | 4 | 210 ± 10 | 4 | 333 ± 9 | 4 | 119 ± 15 | 8 | 13.0 ± 0.3 | ||
| 1500 | 9 | 195 ± 13* | 4 | 316 ± 34 | 9 | 147 ± 22 | 13 | 13.3 ± 0.1 | ||
| 3000 | 6 | 183 ± 14* | 0 | NA | 5 | 195 ± 13 | 5 | 13.1 ± 0.1 | ||
| 4500 | 8 | 169 ± 27* | 4 | 239 ± 57* | 9 | 233 ± 27 | 12 | 14.0 ± 0.2 | ||
| Vitamin D3 [μg/(kg body weight · d)] | <0.00001 | <0.0001 | ||||||||
| 0 | 8 | 219 ± 28 | 0 | NA | 8 | 37 ± 6 | 8 | 11.8 ± 0.2 | ||
| 6 | 5 | 219 ± 7 | 0 | NA | 3 | 57 ± 22 | 3 | 11.7 ± 0.2 | ||
| 60 | 10 | 227 ± 25 | 0 | NA | 8 | 119 ± 11 | 8 | 12.0 ± 0.3 | ||
| 500 | 5 | 172 ± 9* | 0 | NA | 5 | 535 ± 33 | 5 | 13.6 ± 0.2 | ||
| 1500 | 4 | 181 ± 40* | 0 | NA | 4 | 780 ± 19 | 4 | 15.3 ± 0.4 | ||
1
*Significant difference compared with control values, P ≤ 0.05. NA, not applicable; 25(OH)D3, 25-hydroxycholecalciferol.
2
Dose = the supplementation amount of base AIN-76A diet, which contains 1 IU vitamin D3/g diet.
3
Values are means ± SDs.
4
Values are means ± SEMs.