TABLE 2.

Tumor fates in female ^Pirc/+ rats fed diets supplemented with 25(OH)D₃ or vitamin D₃¹

		Tumor fate, %
Dietary compound and dose2	Total colonic tumors followed, n	Grew	Remained static	Regressed	P-value
25(OH)D3 [μg/(kg body weight · d)]
0	40	75	20	5
60	28	64	36	0	0.10
170	25	96	0	4	<0.0001
500	24	83	13	4	0.15
1500	37	78	19	3	0.57
3000	28	71	29	0	<0.0013
4500	67	76	21	3	0.86
Vitamin D3 [μg/(kg body weight · d)]
0	22	91	9	0
6	14	93	7	0	0.60
60	30	73	27	0	0.001
500	31	94	6	0	0.49
1500	11	100	0	0	0.002

¹25(OH)D₃, 25-hydroxycholecalciferol.

²Dose = the supplementation of base diet, which contains 1 IU vitamin D₃/g diet.

³Dose-treated compared with contemporaneous vehicle-treated rats from the vitamin D₃ study.