Table 1.
Differential expression of genes in MEK/ERK signaling pathway in EV71-infected iDCs at different time points
| Gene symbol | EV71/control (Fold changes) | |||
|---|---|---|---|---|
| 1/2 h | 2 h | 8 h | 24 h | |
| KRAS | −1.09 | +1.94 | +2.21 | +1.18 |
| NRAS | −1.05 | +1.08 | +1.42 | −1.07 |
| Raf-1 | +1.07 | +6.51 | −1.25 | −1.21 |
| MEK1 | +1.26 | +1.26 | −1.02 | −1.09 |
| MEK2 | +1.15 | +1.19 | −1.04 | −1.15 |
| ERK1 | +1.27 | −1.16 | −1.10 | −1.20 |
| ERK2 | +1.73 | +1.23 | −1.36 | −1.65 |
| c-Fos | +5.46 | +7.65 | +4.62 | +3.71 |
| c-Jun | +1.64 | +2.05 | +2.78 | +3.67 |
| c-myc | +1.20 | −1.31 | +2.54 | −1.15 |
| Elk1 | −2.57 | +1.94 | +1.69 | +2.47 |
| SOS1 | +1.89 | +16.70 | −1.78 | −1.15 |
| IL-1α | −1.00 | +5.49 | +3.82 | −1.17 |
| IL-2 | +1.23 | +3.12 | +2.76 | +1.79 |
| IL-6 | +1.68 | +2.33 | +2.84 | +1.67 |
| IL-12 | +1.34 | +1.76 | +2.36 | +1.84 |
| IFN-α1 | −1.56 | +1.58 | +1.37 | −1.75 |
| IFN-β | −1.26 | +2.72 | +2.04 | −1.49 |
| IFN-γ | −1.10 | +2.69 | +1.40 | −1.82 |
| TNF-α | +1.28 | +2.27 | +2.62 | +1.41 |
Upregulated and downregulated transcripts are indicated as ‘+’ and ‘–’ values respectively. The values presented in the table are the average of three experiments.