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The c20S subunit β5 and the i20S subunit LMP7 are inhibited in CFZ treated H1993 and SHP77 cells. Cells left untreated or treated for 48 hours with CFZ (48 hour IC50 dosage) were evaluated using the ProCISE assay to determine the level of uninhibited subunits. Mean ± SD are from three pseudo-replicates. Results were statistically significant (***p < 0.001, **p < 0.01) using Student’s t-test.
