Table 1.
Sensitivity of lung cancer cell lines to CFZ and CDDP
| Cell line | CFZ IC 50 (μM) | CDDP IC 50 (μM) | ||||
|---|---|---|---|---|---|---|
| 48 h | 72 h | 96 h | 48 h | 72 h | 96 h | |
| NSCLC | ||||||
| H520 | 0.0769 | 0.0299 | 0.0083 | 19.43 | 23.24 | 18.15 |
| A549 | 0.0901 | 0.0716 | 0.0047 | 25.97 | 26.53 | 9.01 |
| H1993 | 0.0277 | 0.0172 | 0.0216 | 29.60 | 19.58 | 15.52 |
| H460 | 0.1657 | 0.0631 | 0.0364 | 9.02 | 3.72 | 2.69 |
| H1299 | 0.0500 | 0.0293 | <0.0001 | >30.0 | 8.81 | 3.53 |
| SCLC | ||||||
| SHP77 | 0.0614 | 0.0994 | 0.2031 | 12.17 | 21.55 | 28.57 |
| DMS114 | 0.0007 | 0.0002 | <0.0001 | 13.13 | 8.10 | 3.47 |
The determined inhibitory concentrations (IC50 values) represent the level of drug that inhibited cell growth by 50%. IC50 values (μM) of CFZ at 48 and 72 hours are the mean of two or more independent experiments, n ≥ 12. Other IC50 values are the mean of one experiment, n = 6.