Table 3.
a) DS AMKL vs. non-DS AMKL | ||||||||
Gene | Value 'A' | Value 'B' | 'A'/'B' ratio | Location | Data points | SD | SD | |
'A' | 'B' | 'A' | 'B' | |||||
Over-expressed genes | ||||||||
SLITRK6 | 465.5 | 19.5 | 23.860 | 13q31.1 | 27 | 21 | 113.0 | 79.6 |
HDC | 1,119.4 | 65.5 | 17.097 | 15q21-q22 | 36 | 45 | 98.8 | 249.4 |
ZNF587B | 615.0 | 39.3 | 15.643 | 19q13.43a | 43 | 40 | 427.6 | 32.2 |
SOSTDC1 | 111.7 | 8.6 | 12.957 | 7p21.1 | 43 | 45 | 176.5 | 108.4 |
LOC100287628* | 1,381.3 | 107.7 | 12.820 | 16p13.2 | 9 | 7 | 80.2 | 56.8 |
Under-expressed genes | ||||||||
Hs.587427* | 19.8 | 407.8 | 0.049 | 7p15.2 | 18 | 14 | 28.9 | 353.3 |
SPINK2 | 13.1 | 285.1 | 0.046 | 4q12 | 36 | 45 | 81.8 | 115.0 |
Hs.602709* | 15.8 | 370.2 | 0.043 | 11q13.2a | 9 | 7 | 33.1 | 256.9 |
RPS12 | 20.7 | 519.1 | 0.040 | 6q23.2 | 43 | 50 | 113.7 | 213.0 |
Hs.355689* | 3.7 | 624.4 | 0.006 | 18q11.2a | 9 | 7 | 47.3 | 168.4 |
b) DS AMKL vs. MK | ||||||||
Gene | Value 'A' | Value 'D' | 'A'/'D' ratio | Location | Data points | SD | SD | |
'A' | 'D' | 'A' | 'D' | |||||
Over-expressed genes | ||||||||
TMEM241 | 1,036.6 | 17.6 | 58.885 | 18q11.2 | 18 | 8 | 57.7 | 115.8 |
CMBL | 592.4 | 11.7 | 50.759 | 5p15.2 | 27 | 8 | 142.0 | 30.1 |
IFI27 | 467.8 | 11.6 | 40.474 | 14q32 | 36 | 82 | 90.0 | 27.6 |
CSRNP1 | 640.6 | 16.8 | 38.023 | 3p22 | 9 | 8 | 41.3 | 138.3 |
PTGS2 | 2,205.0 | 59.2 | 37.276 | 1q25.2 q25.3 | 63 | 20 | 156.4 | 131.6 |
APOC2* b | 431.7 | 11.7 | 37.044 | 19q13.2 | 54 | 28 | 81.4 | 41.6 |
SLITRK6 b | 465.5 | 13.3 | 35.057 | 13q31.1 | 27 | 10 | 113.0 | 95.6 |
Under-expressed genes | ||||||||
MAP3K10 | 5.4 | 2,352.3 | 0.002 | 19q13.2 | 36 | 19 | 47.4 | 135.1 |
DRD4 | 5.0 | 2,327.6 | 0.002 | 11p15.5 | 36 | 19 | 51.3 | 135.2 |
DLGAP3 | 4.8 | 2,297.9 | 0.002 | 1p35.3-p34.1 | 9 | 7 | 40.8 | 37.6 |
LBX1 | 2.7 | 1,358.5 | 0.002 | 10q24 | 36 | 19 | 46.4 | 152.6 |
TSPAN10* | 7.9 | 4,674.7 | 0.002 | 17q25.3 | 9 | 8 | 55.0 | 46.0 |
c) Non-DS AMKL vs. MK | ||||||||
Gene | Value 'B' | Value 'D' | 'B'/'D' ratio | Location | Data points | SD | SD | |
'B' | 'D' | 'B' | 'D' | |||||
Over-expressed genes | ||||||||
TMEM241 | 2,754.1 | 17.6 | 156.443 | 18q11.2 | 14 | 8 | 89.9 | 115.8 |
CDYL2 | 1,613.5 | 13.1 | 122.994 | 16q23.2 | 7 | 8 | 128.9 | 69.8 |
MPV17L | 1,857.8 | 24.4 | 76.280 | 16p13.11 | 7 | 8 | 119.5 | 65.0 |
ATP6V0D2 | 836.7 | 11.9 | 70.488 | 8q21.3a | 21 | 10 | 169.4 | 82.9 |
CMBL | 757.9 | 11.7 | 64.938 | 5p15.2 | 21 | 8 | 176.2 | 30.1 |
Under-expressed genes | ||||||||
ILDR1 | 13.7 | 4,333.8 | 0.003 | 3q13.33 | 14 | 9 | 98.4 | 63.3 |
HIST3H3 | 3.9 | 1,313.0 | 0.003 | 1q42 | 40 | 19 | 78.0 | 137.9 |
TSPAN10* | 12.1 | 4,674.7 | 0.003 | 17q25.3 | 7 | 8 | 88.1 | 46.0 |
MAP3K10 | 3.9 | 2,352.3 | 0.002 | 19q13.2 | 45 | 19 | 40.1 | 135.1 |
LBX1 | 2.0 | 1,358.5 | 0.001 | 10q24 | 45 | 19 | 85.7 | 152.6 |
Data refer to the following comparisons: a) DS AMKL (pool 'A') vs. non-DS AMKL (pool 'B'); b) DS AMKL (pool 'A') vs. MK (pool 'D'); c) non-DS AMKL (pool 'B') vs. MK (pool 'D'). Value: mean gene expression value normalized across all the pool samples; data points: number of spots associated to an expression value for the locus; SD: standard deviation for the expression value expressed as percentage of the mean. Full results available as additional material (see text). *The segment window contains more than one gene, but the significance is assumed to be maintained because the expression value of this over- or under-expressed gene prevails over the others.
aCytoband not available in Gene was derived from the UCSC Genome Browser [36].
bThis gene, exceeding the limit of five genes for each list, has been shown for its relevance in the Discussion, being recurrent in other comparisons.